Surgical approach for the treatment of thymic carcinoma: 201 cases from a multi-institutional study
Article information
, Yong Soo Choi,1, Jong Ho Cho1, Hong Kwan Kim1, Geun Dong Lee2, Dong Kwan Kim2, Chang Hyun Kang3, Young Tae Kim3, Chang Young Lee4, Jin Gu Lee4, other members of the Korean Association for Research on the Thymus (KART)Abstract
Purpose
This study aimed to compare the outcomes of surgical approach (video-assisted thoracoscopic surgery [VATS] vs. sternotomy vs. thoracotomy) for the treatment ofthymic carcinoma
Methods
We retrospectively reviewed 201 patients with pathologically proven thymic carcinoma who underwent surgicalresection atfour Korean institutions.
Results
From 2007 to 2013, 158 sternotomy, 33 VATS and 10 thoracotomy were conducted forthymic carcinoma. Open group underwent more preoperative biopsy (41.8% and 50% vs. 15.2%, P=0.012) and neoadjuvant treatment (22.2% and 30% vs. 0%, P=0.008) than VATS group. In preoperative imaging, tumor size of VATS group was smaller than sternotomy group (3.8±1.1 cm vs. 5.8±2 cm, P<0.05) and 91% of the VATS group was clinicaltumor-node-metastasis (TNM) stage I. The lengths of chesttube and mechanical ventilation duration, postoperative hospital day and intensive care unit stay were shorterin VATS group than open group (P<0.001). The incidence of postoperative complications of VATS group was lower than sternotomy group (P=0.014). The 5-year overall survival of the sternotomy, VATS and thoracotomy group were 100%, 100% and 87.5%±11.7%, respectively (P=0.107). The 5-year recurrence-free survival rate was not significantly different between the groups (55.4%±4.5%, 67.9%±12.1%, and 87.5%±11.7%; P=0.131)
Conclusion
The VATS approach of surgical treatment for thymic carcinoma can be selectively employed in small (<5 cm) and TNM stage I tumor without compromise of oncologic outcome.
INTRODUCTION
Thymic carcinoma is malignant tumor originating from the thymic epithelium, and it represents a very heterogeneous group of lesions with a wide spectrum of morphologic and prognostic features [1]. Thymic carcinoma is very rare, and only several studies on prognostic factors and treatments have been reported so far. According to most studies, surgicalresection is the mainstay of treatment forthymic carcinoma [2-4].
Conventional transsternal approach has long been accepted as standard method of treatment for thymoma and thymic carcinoma. However, device developments and technological advances led to successful application ofthe minimally invasive approach for thymoma. Recently, minimally invasive procedure such as video-assisted thoracoscopic surgery (VATS) has been performed more frequently for resection of early-stage thymoma. Many literatures have reported the oncologic outcomes of VATS thymectomy for the treatment of thymoma. They showed that VATS thymectomy had less postoperative pain, the length of hospitalization and favorable oncologic outcomes [5-10]. In spite of the advantage of minimally invasive approach, the application of VATS for early-stage thymic carcinoma has controversy because of its poor prognosis and the lack of long-term data.
The present study was aimed to compare the outcomes of surgical approach (VATS vs. sternotomy vs. thoracotomy) for the treatment ofthymic carcinoma.
METHODS
Study cohort
Korean Association for Research on the Thymus (KART) developed a multi-institutional database in 2014, and retrospectively collected the data of 1,663 patients with thymic epithelial tumor who underwent surgical treatment and biopsy between 2000 and 2013 at four Korean institutions. The KART database included patient characteristics, preoperative and pathologic tumor size, preoperative and final pathological Masaoka-Koga stage, pathological World Health Organization (WHO) classification, histologic type,type ofresection, resection status, perioperative therapies, treatment, pattern ofrecurrence, and survival.
A total of 256 patients with pathologically proven thymic carcinoma underwent surgery. Among them, 201 patients underwent thymectomy via sternotomy (n=158), VATS (n=33), or thoracotomy (n=10). Patients who underwent diagnostic (n=17) or debulking surgery (n=8), operation for recurrence (n=16) and operation via other approach including transcervical, clamshell and sternotomy combined with thoracotomy (n=14) were excluded. We were classified histologic type according to latest WHO classification and thymic neuroendocrine tumors and typeB3 thymomas were excluded.
This study was approved by Institutional Review Board of Samsung Medical Center (2017-03-006). Informed consent was waived by the board.
Statistical analysis
Continuous data are described by mean±standard deviation and categoric data by frequencies and percentages. Comparison of preoperative baseline characteristics between three groups was analyzed by Kruskal-Wallis test for continuous variables, and the Pearson’s chi-square and Fisher’s exacttests for categorical variables, when appropriate.
The Kaplan-Meier method was used to analyze overall survival (OS) and recurrence-free survival (RFS). The log-rank test was used to assess the differences between survival rates. Univariate and multivariate Cox regression analyses were employed to evaluated OS and RFS prognostic factors. Chi-square test and Fisher’s exact test, when appropriate, were used to evaluate the difference between groups. The statistical analysis was performed using SAS version 9.4 (SAS Institute Inc., Cary, NC, USA).
RESULTS
Patient characteristics
From January 2000 to December 2013, a total of 201 patients (158 sternotomy, 33 VATS, and 10 thoracotomy) were included in this study. Sex, age, smoking history, symptom, performance status, pulmonary function, body mass index, and comorbidity were not different between the groups. Open group including sternotomy and thoracotomy underwent preoperative biopsy and neoadjuvant treatment more frequently than VATS group. Baseline patient characteristics are summarized in Table 1.
Patient characteristics
Factors associated with undergoing VATS
Patients who underwent VATS had tumor less than 5 cm (P<0.001) and clinical tumor-node-metastasis (TNM) stage I International Association for the Study of Lung Cancer/International Thymic Malignancies Interest Group (IASLC/ITMIG) 8th edition (P=0.001). Furthermore, tumor without vascular invasion on preoperative computed tomography (CT) were subjected to VATS (P=0.049). Tumor location, size, TNM stage and invasion of surrounding tissue on preoperative CT image are described in Supplementary Table 1.
Surgical outcomes
The operation time of VATS was shorterthan sternotomy and thoracotomy (P<0.001). The amount of blood loss and the incidence of transfusion were lower in the VATS group than in the open group (P<0.001 and P=0.005).
In terms of extent of resection, most of the sternotomy group underwent total thymectomy (P<0.001), and lymph node dissection was performed more frequently in open group (P=0.015). Furthermore, additional procedures including resection of lung, pericardium, innominate vein and phrenic nerve were conducted more frequently in open group (P<0.001). Complete resection was not different between the groups. Details are shown in Table 2.
Operative findings, procedures and pathologic findings
One patient of sternotomy group was died within postoperative 30 days. The lengths of postoperative hospital stay (POHS), intensive care unit(ICU) stay and chesttube duration were shorter in the VATS group than in the open group (P<0.001). The incidence of postoperative complications of the VATS group was lower than those of open group (P=0.014). Details ofthe incidence of complications are shown in Table 3.
Postoperative outcome
Survival and oncologic outcomes
The median follow-up duration was 50.3 months. The 5-year OS rates ofthe sternotomy and VATS group were 100%, while thoracotomy group was 87.5%±11.7% (P=0.107). The 5-year RFS rates were not significantly different between the groups (55.4%±4.5% for sternotomy group, 67.9%±12.1% for VATS group, 32.8%±18.3% for the thoracotomy group, P=0.131). These graphs are presented in Fig. 1.
Overall survival (A) and recurrence-free survival (B) of 201 patients. VATS, video-assisted thoracoscopic surgery.
In terms of recurrence patterns, local recurrence was not different between the groups, while the thoracotomy group had more regional recurrence than the VATS group (30% vs. 3%, P=0.04). Details are shown in Table 4.
Pattern of recurrence
Subgroup analysis for tumor less than 5 cm and clinical TNM stage I
A total of 55 patients (28 sternotomy and 27 VATS) had tumor less than 5 cm and clinical TNM stage I. The lengths of POHS, ICU stay and chest tube duration were shorter in the VATS group than in the sternotomy group (P<0.001). The incidence of postoperative complications of the VATS group did not differ from the sternotomy (P=0.252). Details are described in Table 5.
Postoperative outcome of patients with tumor less than 5 cm and TNM stage I
The 5-year OS rates of subgroup were 100% in both groups. The 5-year RFS rates of subgroup were not significantly different between the groups (70.7%±9.6% for sternotomy group, 55.8%±15.4% for VATS group, P=0.960). These graphs are illustrated in Fig. 2. The pattern of recurrence of subgroup was not different between the groups (Table 6).
Overall survival (A) and recurrence-free survival (B) of patients with tumor less than 5 cm and tumor-node-metastasis (TNM) stage I. VATS, video-assisted thoracoscopic surgery.
Pattern of recurrence of patients with tumor less than 5 cm and TNM stage I
Predictors of OS and RFS
The predictors of OS and RFS identified by univariable and multivariable analysis are listed in Tables 7, 8. In multivariable Cox regression analysis of prognostic factors, surgical approach was not significantly associated with OS (P=0.138), although neoadjuvant radiotherapy was associated with poor OS (hazard ratio, 7.2; 95% confidence interval, 1.6 to 32.46; P=0.01). The multivariable Cox regression analysis for RFS showed pathologic TNM stage was a significant prognostic factor of RFS (P=0.045). However, VATS had not effect on either OR or RFS.
Cox regression analysis of prognostic factors of overall survival
DISCUSSION
Thymic carcinomas are very rare, and most literatures about thymic carcinomas are retrospective, small-case, single-center studies. Only a few retrospective large-sample multicenter studies on long-term outcome of thymic carcinoma were reported in the United States (Surveillance, Epidemiology, and End Results database, n=290), Europe (European Society of Thoracic Surgeons database, n=229), Japan (Japanese Association for Research of the Thymus database, n=306), and China (Chinese Alliance for Research of Thymoma database, n=369) [2,11-13]. In Korea, the KART developed a multi-institutional retrospective database in 2014, and collected the data of thymic epithelial tumor, including thymic carcinoma.
In early stage thymic tumor, surgery for complete resection has remained the mainstay of curative treatment because complete resection was a significant prognostic factor in the many studies of thymic carcinoma [2,14]. Traditionally, this has been conducted with open procedures, especially median sternotomy. According to the European Society of Medical Oncology (ESMO) guidelines on thymic tumors, the standard surgical approach for resectable thymic epithelial tumor remains median sternotomy (grade IV, level A) [15]. More recently, due to the widespread use of VATS, there has been a progressive adoption of these techniques in surgery for thymic carcinoma. The ESMO guidelines suggest that minimally invasive surgery is an option for early stage tumor in the hands of appropriately trained surgeons. Several advantages of VATS forthe treatment ofthymic tumors have been known in a number of literatures in the last decade. VATS provide non inferior oncologic outcomes than open approach and is associated with shorter length of hospital stay, reduced blood loss and duration of chest tube [9,14-17]. Unfortunately, most of these literatures are retrospective studies and no randomized clinical study has been published because ofthe rarity ofthymic tumor.
In the present study, most patients with thymic carcinoma who underwent VATS approach had tumor with less than 5 cm (mean tumor size, 3.8±1.1 cm) and TNM stage I (90.9%). Therefore, we analyzed 55 patients (28 sternotomy and 27 VATS) who had tumor with less than 5 cm and clinical TNM stage I according to the approach of surgery. VATS was associated with shorter operation time, lower blood loss,reduced lengths of POHS, ICU stay, and chest tube duration. Furthermore, the 5-year OS and RFS rates and pattern of recurrence were not significantly different between the groups. Therefore, VATS can be applied to patients who had thymic carcinoma with less than 5 cm and clinical TNM stage I.
VATS was performed mostly in patients who did not confirm histology by preoperative biopsy according to ourresult. The National Comprehensive Cancer Network recommends that surgical biopsy should be avoided if a resectable thymic tumor is strongly suspected based on clinical and radiologic features [18]. However, histology of the thymic tumor is difficult to distinguish by imaging in case of small tumor with no lymphadenopathy [19]. In our series, although thymic tumor revealed to be thymic carcinoma (WHO type C) intraoperatively or postoperatively, VATS can be acceptable if complete resection was achieved.
The present study has limitations. First,the number of cases is small because of the rarity of thymic carcinoma, with only 201 cases over 7 years. Second, this is retrospective study, and selection bias exists. Surgeons would preferred VATS for less invasive tumor such as small size without invasion to innominate vein or great vessels on preoperative CT. Therefore, we analyzed subgroup who had tumor with less than 5 cm and TNM stage I. Third, the follow-up period after surgery is slightly insufficient. Because patients with thymic carcinoma have good prognosis, a follow-up time of 10 years or more may be necessary to identify substantial long-term outcomes. Fourth, surgical techniques, the degree of individual skills, and postoperative care of individual center could not be evaluated.
In conclusion, the VATS was applied for tumor less than 5 cm and TNM stage I. The VATS group had shorter duration of chest tube, mechanical ventilation, postoperative hospital day, and lower incidence of postoperative complication. The 5-year OS and RFS was not significantly different between the groups. Therefore, the VATS approach of surgical treatment for thymic carcinoma can be selectively employed in small and TNM stage I tumor without compromise of oncologic outcome.
Cox regression analysis of prognostic factors of recurrence-free survival
Notes
No potential conflict of interest relevant to this article was reported.
AUTHOR CONTRIBUTIONS
Conception or design: YJJ, YSC.
Acquisition, analysis, or interpretation of data: YJJ, YSC, JHC, HKK, GDL, DKK, CHK, YTK, CYL, JGL.
Drafting the work orrevising: YJJ, YSC.
Final approval ofthe manuscript: YJJ, YSC.
Acknowledgements
Members of the KART Study Group: Sumin Shin, Jong Ho Cho, Hong Kwan Kim, Jhingook Kim, Jae Il Zo, Young Mog Shim (Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea); Geun Dong Lee, Su Kyung Hwang, Sehoon Choi, Hyeong Ryul Kim, Yong-Hee Kim, Dong Kwan Kim, Seung-Il Park (Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea); Samina Park, Kwan Yong Hyun, Yoohwa Hwang, Hyun Joo Lee, In Kyu Park, Chang Hyun Kang, Young Tae Kim (Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea); and Chang Young Lee, Jin Gu Lee, Hyo Chae Paik, Dae Joon Kim, Kyung Young Chung (Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea).